In 2012, Angela Renée Simpson made her triumphant Chicago Lyric Opera debut as Queenie in their co-produced production of Rogers and Hammerstein's classic Show Boat. She also made her concert debut at the Malta Arts Festival under the baton of Maestro Wayne Marshall this year.
The soprano made a number of concert debuts in the 2011 with Teatro Maggio Musicale Fiorentino, in Florence Italy; the Iceland Symphony Orchestra in Reykjavik, Iceland; the Orchestra Sinfonica di Milano Giuseppe Verdi in Milan, Italy and the Royal Stockholm Philharmonic in Stockholm, Sweden.
In 2009, she made her debut as Serena in Graz, Austria, in a concert version of George Gershwin's much acclaimed opera Porgy and Bess at the Styriarte Festival, under the baton of Maestro Nikoaus Harnoncourt. The performances were recorded live and will be released this November under the RCA Red Seal label. In 2008, the soprano also starred in the same role in Opéra Comique's premiere production in Paris, France. In previous seasons, she sang with Washington National Opera, Los Angeles Opera, San Francisco Opera, La Scala Opera, Houston Grand Opera, San Diego Opera, Miami Opera, Piedmont Opera, and New York City Opera. In 2005, she performed the role of Cilla in Michigan Opera Theatre's world premiere production of Richard Danielpour's Margaret Garner, starring Denyce Graves. She repeated the role with Opera Carolina in 2006. In 2002, she performed with the New York City Opera in the televised broadcast Live from Lincoln Center as Serena in Porgy and Bess.
In 2009, she performed in Cagliari and Naples, Italy, with the Teatro Lirico, and with the Teatro San Carlo respectively. In 2008, she made her Carnegie Hall debut, with the New York Pops Orchestra in a Gerswhin tribute under the baton of Maestro Andrew Litton. In the same year she also made her debut with the Alabama Symphony Orchestra under the baton of Maestro Justin Brown and with the Accademia di Santa Cecilia Orchestra with Maestro Wayne Marshall at the podium. She has been heard with the Hartford Symphony, Minnesota Orchestra, the Dallas Symphony, the Colorado Springs Symphony, the Charleston Symphony, the Novaya Opera Theater in Russia, in Weill Recital and with the Bravo Music Festival singing Mozart's Requiem, Faure's Requiem, Bernstein's Jeremiah Symphony, Mozart's Grand Mass in C minor, and Barber's Knoxville 1915. She sings Ariadne in Ariadne auf Naxos, Santuzza in Cavalleria Rusticana, Amelia in Un ballo in maschera, Leonora in Il trovatore, Serena in Porgy and Bess and Aida in Aida and has sung with Maestros Nikolaus Harnoncourt, Andrew Litton, John DeMain, Wayne Marshall and Eugene Kolobov to name a few.