Mary Lynn Rajskub and Karen Kilgariff -- both exiles of HBO's cult-favorite comedy hour Mr.Show -- are making a splash via stand-up. Rajskub is known for her dementedly funny act, which sometimes leaves audiences a tad perplexed, but most definitely entertained. Meanwhile, Kilgariff has earned a reputation as a solid laugh-getter with her wry brand of self-deprecating stand-up. Girls Guitar Club couples Rajskub and Kilgariff in a "Tenacious D" - style musical comedy which lampoons that most deserving of targets: the simpering chick-rocker. Both have appeared in numerous sitcoms and films, including Veronica's Closet, Shasta McNasty, and Magnolia.