In 1974 Marie-Hélène Estienne worked with Peter Brook on the casting for Timon of Athens, and consequently joined the Centre International de Créations Théâtrales (CICT) for the creation of Ubu aux Bouffes in 1977. She was Peter Brook's assistant on La tragédie de Carmen, The Mahabharata, and collaborated to the staging of The Tempest, Impressions de Pelléas, Woza Albert!, La tragédie d'Hamlet (2000). She worked on the dramaturgy of Qui est là. With Peter Brook, she co-authored L'homme qui and Je suis un phénomène shown at the Théâtre des Bouffes du Nord. She wrote the French adaptation of Can Themba's play Le costume, and Sizwe Bansi est mort, by authors Athol Fugard, John Kani, and Winston Ntshona.